also praised her performance in the film, citing her "subtle expressions of love, fear and anxiety work well for the film" and that she "looks beautiful and has done her role with consummate ease".Samantha then worked on Gautham Menon's trilingual romantic drama film, and played the leading female role of Nithya in the Tamil, Telugu and Hindi versions of the film, shooting scenes simultaneously back-to-back with three different actors.The film spanned three periods in the life of a couple, focusing on their romantic relationship at school, college and in their late twenties.Samantha revealed that she knew Gautham would want to work with her again and immediately accepted the opportunity to portray the roles when she was offered the film.Jeevi from Idlebrain.com, wrote that "Samantha's debut is one of the best heroine debuts in Telugu cinema" and noted that the "minute expressions she gave spoke volumes about her", whilst labelling the film as a "classic".Ye Maaya Chesave fetched her the Filmfare Award for Best Debut Actress and a Nandi Award.She felt that she "could relate to the attributes and the circumstances the character goes through" and described Nithya's character as "close to her".
During the period, Samantha had also been signed on two feature in two big budget projects in Tamil, Mani Ratnam's Kadal (2013) and Shankar's I (2015) but was forced to opt out from both films, since she was suffering from a skin disease and could not work for two months during mid 2012.
The shooting for the film began in August 2007, with Samantha, then briefly credited with the screen name Yasodha, joining the team later in the year.
Samantha then went on to feature in Vamsi Paidipally's Telugu film Brindaavanam (2010) in which she had a supporting role alongside NTR Jr and Kajal Aggarwal.
Since then, she has primarily opted to appear in the leading female role in hero-centric Telugu and Tamil films, earning box office success with films including Dookudu (2011), the family dramas Seethamma Vakitlo Sirimalle Chettu (2012) and Attarintiki Daredi (2013) and AR Murugadoss's Tamil action film, Kaththi (2014).
Her work in the film A Aa (2016) also won positive reviews and won Samantha her fourth Filmfare Award, while her next films Theri (2016), 24 (2016) and Mersal (2017) also were commercially successful.